Genetically Encoded Biomaterials
Engineering phase-transitioning elastin-like polypeptides to develop technologies for biotechnology and medicine
Our research in genetically encoded biomaterials focuses on intrinsically disordered proteins (IDPs). One class – elastin-like polypeptides (ELPs) – are polymers of a Val-Pro-Gly-Xaa-Gly motif found in tropoelastin that display a tunable lower critical solution temperature (LCST) phase behavior. Because of the ELP’s biocompatibility and tunable phase behavior, we have engineered and developed ELPs across several applications. These applications include, but are not limited to: ELP tags for simpler protein purification, self-assembling nanoparticles for anticancer drug delivery, injectable depots for sustained delivery of biologics, partially ordered polypeptide scaffolds for tissue repair, and formation of synthetic biomolecular condensates. Find some recent publications below.